Estrogen-Modulated Response of Breast Cancer to Vitamin D and its Analogs: Role of IGF

Abstract

The purpose is to assess how estrogen (E2) alters the antiproliferative effects of 1,25(OH)2 D3, and to determine how this interaction is modified in the presence of 1C1164,384 (antiestrogen). IGF-I and II exhibit strong proliferative effects on breast cancer cells. The scope herein will determine whether 1 ,25(OH)2 D3 affects IGF-I-R function, or production of its ligand IGF-II, and whether there is a difference in effects on ER+ and ER- cells.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA338874

Entities

People

  • Cheryl D. Love-schimenti

Organizations

  • Northern California Institute for Research and Education

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Epithelial Cells
  • Estrogens
  • Growth Factors
  • Insulin
  • Neoplasms
  • Phosphorylation
  • Production
  • Tumor Cell Line
  • Vitamin D

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.