Deprenyl and Protection Against Mammary Tumors

Abstract

In the preliminary studies conducted in our laboratory, administration of deprenyl, a monoamine oxidase-B (MAO-B) inhibitor, enhanced immunological functions IN VITRO INTERLEUKIN- 2 (LL-2) production and NK cell activity, reversed the age-related loss of noradrenergic fibers in the spleens of old male rats, and prevented the development of carcinogen-induced mammary tumors in young female rats. The focus of the present study was to investigate whether treatment of young Sprague-Dawley female rats with deprenyl would inhibit the development and growth of 9, 10-dimethyl-1,2-benzanthracene- (DMBA-) induced mammary tumors by augmenting T-cell functions.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA338899

Entities

People

  • David L. Felten

Organizations

  • University of Rochester

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Cancer
  • Carcinogens
  • Cells
  • Chemical Compounds
  • Chemistry
  • Inhibitors
  • Laboratory Animals
  • Liquid Chromatography
  • Lymphatic System
  • Lymphocytes
  • Materials
  • Neoplasms
  • New York
  • Peptide Growth Factors
  • Production

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Immunology
  • Molecular Biology and Genetics