Relationship Between Scavenger Receptors and uPA:PAI-l and uPA Receptors in Breast Cancer
Abstract
The overall goal of this research is to gather detailed information about the cellular distribution and activities of components of the uPA-system in relation to scavenger receptors and RAP in normal and breast cancer cells. We have especially noted a number of differences between the cell lines in either expression levels of these proteins or their localization. Scavenger receptors show higher expression levels in estrogen-insensitive compared to estrogen-sensitive and normal cells. Expression of both receptors seems to correspond with the malignant phenotype of these breast cancer cell lines. Immunocytochemical and immunochemical studies documented similar distribution pattern and expression levels for RAP in all cell lines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA338927
Entities
People
- Marilyn Farquhar
- Ralf-pater Czekay
Organizations
- University of California, San Diego