The p16 Pathway In Breast Cancer and Senescence Control
Abstract
The main hypothesis of this proposal is that breast cancer cells utilize various alternative mechanisms to circumvent a major restriction point in the G1 phase of cell cycle progression. Furthermore, we speculate that the sum of the various subsets of tumors with abnormalities in either player of the cell cycle inhibitor p16 pathway, accounts for a very significant number of breast cancers. It is a main objective of this research project to elucidate the overall extent of p16 involvement in the tumorigenesis of the breast. An additional major goal is to evaluate whether p16 fulfills all the criteria to be considered a senescence control gene.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA338940
Entities
People
- Claudio M. Aldaz
Organizations
- The University of Texas MD Anderson Cancer Center