Breast Mucin Tumor-Specific Epitopes for Cancer Immunotherapy

Abstract

The objectives of the research program are to study the structure-immunogenicity relationships of a hypoglycosylated human tumor-specific mucin common to breast and other adenocarcinomas. Hypo-glycosylation of breast mucin leads to exposure of a tumor-specific epitope (TSE). The structural and immunogenic properties of the TSE are being examined using synthetic mucin peptides and recombinant mucin proteins that contain the TSE and/or mutations in potential glycosylation sites surrounding the TSE.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA339039

Entities

People

  • Kenneth E. Dombrowski

Organizations

  • Texas Tech University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Carbohydrates
  • Cell Line
  • Cells
  • Chemistry
  • Immunogenicity
  • Immunotherapy
  • Lymphatic System
  • Lymphocytes
  • Materials
  • Molecules
  • Neoplasms
  • Proteins
  • Recombinant Proteins
  • Spectra
  • Spectroscopy

Readers

  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech