Expression of the Epidermal Growth Factor Receptor Family in Transgenic Mouse Models of Human Breast Cancer

Abstract

Transgenic mice expressing the activated neu oncogene in the mammary epithelium develop mammary tumors with relatively short latency. To explore the role of the EGFR in tumorigenesis in this system we have recently crossed these MMTV/activated neu strains to a naturally occurring mouse mutant which expresses a catalytically inactive EGFR (Waved-2 strain).

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA339104

Entities

People

  • William J. Miller

Organizations

  • McMaster University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Chemistry
  • Diseases And Disorders
  • Epithelium
  • Growth Factors
  • Mammary Glands
  • Neoplasms
  • Observation
  • Proteins
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics