Use of Cytokines to Prevent Breast Cancer Growth and Progression

Abstract

The current project extends two sets of observations: (1) Original work from our laboratories which showed that a cytoplasmic extract from transformed cells (TKO) interrupts the Stat1 signal transduction pathway of IFN-alpha/beta 28; and (2) published work of others showing that human breast cancer cells can secrete PRL and thus might autonomously activate Stat 1 by tyrosine phosphorylation.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA339111

Entities

People

  • Philip M. Grimley

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Gene Expression
  • Growth Factors
  • Interferon
  • Medical Personnel
  • Neoplasms
  • Peptides
  • Proteins
  • Two Dimensional

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics
  • Systems Analysis and Design