Amplified Genes in Breast Cancer: Molecular Targets for Investigation and Therapy

Abstract

We showed that extrachromosomally amplified genes in double minute chromosomes (DMs) are removed from tumor cells through preferential incorporation into micronuclei that are generated in S-phase. This process is enhanced by DNA synthesis inhibitors, and requires p53 inactivation. In the past year, we developed technology that enables visualization of chromosome dynamics in living cells.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA339114

Entities

People

  • Geoffrey M Wahl

Organizations

  • Salk Institute for Biological Studies

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Structures
  • Chromosomes
  • Confocal Microscopy
  • Dynamics
  • Enzyme Inhibitors
  • Genetics
  • Intranuclear Space
  • Materials
  • Medical Personnel
  • Microscopy
  • Neoplasms
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Systems Analysis and Design