Octanol-Water Partition Coefficients by Capillary Electrophoresis
Abstract
We have investigated the use of capillary electrophoresis (CE) for the modeling of octanol-water partition coefficients. Reversed-phase liquid chromatography (RPLC) is likely the most used method for estimation of octanol-water partition coefficients, with correlations from approximately 0.5 to 0.000, depending on the column and compounds tested. RPLC will never be a reliable method, however, because of variability in the chemistry of the stationary phase from column to column. Capillary electrophoresis is a much simpler system, as there is no true stationary phase, and there should be dramatically less variation from laboratory to laboratory. We have shown that CE can give a single point estimate of the octanol-water partition coefficient. Specifically, micellar electrokinetic capillary chromatography (MEKC), the micellar variant of the CE experiment, was evaluated as an a priori predictor of n-octanol-water partition coefficients (log Ko/w).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1997
- Accession Number
- ADA339212
Entities
People
- John G. Dorsey
Organizations
- Florida State University