A Novel Role for C/EBP in Mammary Development and Breast Cancer

Abstract

The objective of this fellowship is to characterize the roles which C/EBP alpha and C/EBP beta play in normal mammary gland development and breast cancer. In general, C/EBP alpha is predominantly expressed at high levels in terminally differentiated, growth arrested cells and the C/EBP beta isoforms, most notably LIP, are expressed at high levels in actively proliferating cells. LIP can act as a dominant negative isoform, which when dimerized with other C/EBP family members suppresses transcriptional activity Consequently, an increase in LIP levels may inhibit terminal differentiation and lead to excessive cellular proliferation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA340339

Entities

People

  • Cynthia A. Zahnow

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Biomedical And Dental Materials
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Epithelial Cells
  • Genetics
  • Health Services
  • Mammary Glands
  • Neoplasms
  • Polymerase Chain Reaction
  • Polymeric Films
  • Proteins

Readers

  • Molecular Biology and Genetics