Role of CD44 in Tumor Progression
Abstract
The present research project consists of two major parts. In the first part, we examined the hypothesis that CD44 allows tumor cells to bind and degrade hyaluronan and this, in turn, stimulates their vascular supply. In Tasks 1 through 4, we investigated this hypothesis by examining the effects of CD44 expression on tumor progression. However, we could not find any obvious correlation between the distribution of HA and blood vessels (endothelial cells). In the second part, we have explored the possibility of targeting lung metastases with proteins from cartilage (PG) that can bind to hyaluronan that is closely associated with these tumor cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA340667
Entities
People
- Charles Underhill
Organizations
- Georgetown University