Mechanism of Thyroid Hormone-Induced Osteoporosis.
Abstract
The goal of the research is to determine the mechanism by which thyroid hormone (T3) affects bone, and the cause of the osteoporosis that can result when T3 concentrations are excessive. Our previous publications had shown that T3 increases the production of the bone growth factor insulin-like growth factor-I (IGF-I) in osteoblastic cells and promotes the production of the osteoclastogenic cytokine interleukin-6. The experiments carried out during the first grant year evaluated models that could be used to study the roles of these local factors in the anabolic and resorptive effects of T3 on bone and the molecular mechanisms by which T3 stimulated their production. The early findings using antibodies to the IGF-I and IL-6 receptors and antisense oligonucleotides to the IGF-I receptor support a role for these factors in the thyroid hormone effects. Studies at the level of gene expression show T3 augmentation of IL-6 production in human and rodent osteosarcoma cells, a lack of effect of T3 on IL-i receptor expression, and T3 potentiation of parathyroid hormone-induced IL-6 mRNA production.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA340690
Entities
People
- Paula H. Stern
Organizations
- Northwestern University