Defining the Smallest Common Region of Chromosome 17p that is Deleted in Sporadic Breast Tumors
Abstract
Germilne mutations in breast cancer susceptibility genes account for 8% of all breast cancer cases. BRCA1 on 17q12 and BRCA2 on 13q12-13 are implicated in 50%-60% of breast cancer families. and they are both likely to also have an impact in sporadic breast cancers and there is evidence for families with linkage to these loci. We propose to ascertain 8 ethically diverse (non Caucasian) families linked to putative BRCA3 loci on chromosome 8p, and to investigate whether a recently isolated prostate cancer metastases suppressor gene, KAII, is involved in the genetic alterations of inflammatory breast cancer, a particularly aggressive form of breast cancer which accounts for 15% of all cases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA340961
Entities
People
- Max S. Wicha
- Sofia D Merajver
Organizations
- University of Michigan