Interphase Cytogenetics in Breast Tumors P53 Gene Alterations

Abstract

HE PURPOSE OF THIS RESEARCH IS TO COMPARE NUMERICAL CHROMOSOME ABERRATIONS AND P53 GENE ALTERATIONS IN 250 NODE-NEGATIVE BREAST CANCERS TO 250 NON-POSITIVE BREAST CANCERS AND THEIR SURVIVAL. SCOPE: Interphase cytogenetics will be performed in paraffin sections utilizing biotinylated probes specific for centromeric regions of chromosomes 1, 8, 11, 13, 17, 18, and X. Chromosome profiles based on 300 tumor cells will be generated for each patient.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1993
Accession Number
ADA341896

Entities

People

  • Isabell A. Sesterhenn

Organizations

  • Armed Forces Institute of Pathology

Tags

DTIC Thesaurus Topics

  • Alkanes
  • Amplification
  • Biomedical Research
  • Breast Cancer
  • Carcinoma
  • Cells
  • Chromosome Aberrations
  • Chromosomes
  • Cytogenetics
  • Genetics
  • Laboratory Animals
  • Materials
  • Neoplasms
  • Recombinant Dna
  • Statistical Analysis
  • Survival

Readers

  • Molecular and genetic basis of cancer.