Risk Factors for Chorioamnion Infection and Adverse Pregnancy Outcome Among Active-Duty Military Women and Dependent Women
Abstract
Cervicovaginal ureaplasmal infection alone is not predictive of preterm birth. Only a subpopulation of women infected in the lower genital tract are at risk for chorioamnion invasion and premature birth. The major goal of the proposed study is to identify microbiologic factors that predispose to and/or predict chorioamnion invasion and premature birth. This study will determine if the presence of bacterial vaginosis is a risk factor for ureaplasmal invasion of the chorioamnion. 1755 women have been enrolled to date. Vaginal cultures from 1497 of these women have been assessed for Ureaplasma urealyticum colonization and 564 have been assessed for Bacterial Vaginosis (BV). 731/149 or 48.8% are culturally positive for U. urealyticum and 101/564 or 18% of the gram stains are positive for BV. At delivery, the isolation rate of U. urealyticum from the vagina, placental tissues, amniotic fluid, and infant's noses is 60%, 10%, 14.8%, and 23% respectively. Gram stains for BV assessment at delivery is 16%. The persistence of U. urealyticum during pregnancy in this study sample is high, irrespective of delivery type (Cesarean section with intact membranes, Cesarean section with ruptured membranes, or vaginal delivery). This is important because of the asymptomatic nature of U. urealyticum and its detrimental effects in low birth pregnancies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA342258
Entities
People
- Gail H. Cassell
Organizations
- University of Alabama