Preclinical Toxicology Studies for New Drugs and Vaccines.

Abstract

This project evaluated the toxicity and safety of several drugs under development. During the contract, tasks conducted included: mutagenicity tests; developmental toxicity studies in rats and rabbits; acute toxicity studies in rats and mice; two, four and thirteen week toxicity studies in rats and dogs; a six month toxicity study in rats; fertilitylearly embryonic development studies, in rats; a perinatal toxicity study in rats; and a one year toxicity study in dogs. Drugs studied included: WR242S ii Tartrate, WR2386OS Succinate, Halofantrine HCl, Pyridostigmine Bromide, WR6O26 Dihydrochioride, H1-6 Dichloride, WR26941O, Atropine, WR279396, and Ampicillin.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1998
Accession Number
ADA343280

Entities

People

  • Barry D. Levine

Organizations

  • University of Illinois at Chicago

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Fertility
  • Hematologic Diseases
  • Lymphatic System
  • Macrophages
  • Medical Personnel
  • Mutagenicity Tests
  • Pyridostigmine Bromide
  • Toxicity

Readers

  • Parasitology and Pharmacology of Malaria.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech