Biochemistry and Molecular Mechanisms of Wingless Action.
Abstract
Our goal is to understand how intercellular signaling pathways are used to regulate growth and differentiation in multicellular organisms. We have focused on the wingless/Wnt1 pathway, and in particular, on the extracellular events that mediate wingless signaling. Studies with transgenic S2 cells expressing either DFrizzled1 or DFrizzled2 demonstrate that WG can interact with more than one Frizzled receptor. Biochemical analyses of partially purified Wingless also suggest that glycosaminoglycans act as important accessory molecules or co-receptors for Wingless signaling. Experiments are now underway to test whether extracellular glycosaminoglycans mediate ligand-receptor specificity as well.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA344733
Entities
People
- Susan Cumberledge
Organizations
- University of Massachusetts Amherst