Protein Kinase C Processes and Their Relation to Apoptosis in Human Breast Carcinoma Cells

Abstract

Cdc25 phosphatases are possible key oncogenes in human breast carcinoma. In collaboration with Dr. Peter Wipf in the department of Chemistry at the U. of Pittsburgh, it was decided that a promising project would be the development of Cdc25 phosphatase specific inhibitors using combinatorial techniques to test the hypothesis that it is the phosphatase activity that is the main oncogenic function of these oncogenes. We generated a refined library of novel, phosphate-free, small-molecule compounds synthesized by a parallel, solid-phase combinatorial-based approach.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1997
Accession Number
ADA344905

Entities

People

  • John S. Lazo
  • Robert L. Rice

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Amines
  • Amino Acids
  • Breast Cancer
  • Cell Physiological Processes
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Neoplasms
  • Organic Chemistry
  • Proteins
  • Small Molecules

Fields of Study

  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and Cellular Biochemistry
  • Organizational Process Management (OPM).