High Temperature Superconductor RF Probes for Breast Cancer.
Abstract
Nuclear magnetic resonance (NMR) imaging and spectroscopy have emerged as one of the most promising techniques to improve the specificity of the diagnosis and staging of breast cancer. They have been widely used in studying of the tumor energy metabolism, vascular and oxygenation and response to treatment of breast cancer. NMR techniques intrinsically have weak signals, which limit the ultimate resolution and sensitivity. We propose to use high temperature superconductor (HTS) to construct NMR probe to reduce the probe noise and significantly improve the detection sensitivity of the technique. The probe will be constructed with YBCO material and to be tested on two well defined experiments: an in vivo cell metabolism study on a 9.4 T spectrometer and an in vivo tumor bearing animal study on a 4.7 T scanner. During the first year of the study, several tasks are completed. There are: (1) construction of and testing a cell perfusion apparatus (2) start to grow MCF7 cells (3) designing and construction of a HTS probe and a room temperature probe (4) to upgrade the software on the 200 MHz NMR machine (S) implementing the diffusion imaging technique (6) to relocate the 400 MHz machine and renovation of the laboratory.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA344925
Entities
People
- Paul C Wang
Organizations
- Howard University