Acquired Secondary Events in the Pathogenesis of Hereditary Breast Cancer.
Abstract
Mutation of the BRCA1 gene accounts for most families with an inherited predisposition to breast and ovarian cancer and many families with multiple cases of breast cancer only. The inheritance of a gremlin mutation of the BRCA1 gene, although associated with a markedly increased incidence of breast cancer, is not solely responsible for the development of breast cancer in predisposed women and multiple other acquired steps appear to be required for the development of breast tumors in predisposed women. In this study we have identified a number of women with BRCA1 mutations for which tumor tissue is available for study. No models currently exist for the study of breast cancers associated with BRCA1 mutations. No breast cancer cell lines have been reported to date which derive from a BRCA1 predisposed individual. Reported here is the characterization of a breast cancer cell line mutant for BRCA1 which will be useful not only for studying secondary acquired changes in BRCA1 carriers, but will also be useful for studying the function of BRCA1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA344932
Entities
People
- Gail E. Tomlinson
Organizations
- University of Texas Southwestern Medical Center