Genetic and Dyanmic Analysis of Murine Peak Bone Density
Abstract
During the first year of this grant-in-aid, we have expanded the C57BL/6J, C3H/HeJ, and B6C3Fl mouse colonies to provide mice for biochemical and histomorphometric analyses at ages from 8 to 30 weeks. Serum bone formation marker data gathered include osteocalcin and alkalin phosphatase. Our best serum bone resorption marker was osteoclastic acid phosphatase. In addition, we have measured serum Insulin- like Growth Factor-I, mouse Growth Hormone, and 24hr urinary creatinine. Morphologic data gathered on duel-labeled bone samples include cross-sectional areas, labeled surfaces, mineral apposition rates, and bone formation rates at periosteal and endosteal surfaces of tibias.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADA345442
Entities
People
- Wesley G. Beamer