Potential Amelioration of Major Limiting Toxicities in Intensive High Dose Chemotherapy of Mammary Tumors

Abstract

High dose escalation and dose intensity are known factors for eradication of tumors an possibly overcoming of drug resistance in breast cancer chemotherapy. During the past year, we evaluated the ability of swainsonine to confer protection against lethality associated with high-dose sequential administration of doxorubicin before high-dose combination of cyclophophamide (CPH)- methotrexate (MTX)- 5-fluorouracil (5-FU) CMF.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA345457

Entities

People

  • Oladipo Oredipe

Organizations

  • Howard University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkaloids
  • Animals
  • Bone Marrow
  • Breast Cancer
  • Chemotherapy
  • Drug Resistance
  • Intensity
  • Laboratory Animals
  • Lethal Dosage
  • Lethality
  • Methotrexate
  • Neoplasms
  • Pilot Studies
  • Survival
  • Three Dimensional
  • Toxicity

Fields of Study

  • Medicine
  • Physics

Readers

  • Allergy and Immunology.
  • Oncology (Cancer Research).
  • Systems Analysis and Design