The Role of Protein Kinase-C in Breast Cancer Invasion and Metastasis

Abstract

In a study of the effects of treatment with the anti-P.C. acting drug Bryostatin-1, the levels of protein kinase C isoforms in patient peripheral blood lymphocytes was studied. While the levels of many of the isoforms was quite variable, protein kinase C eta was frequently elevated shortly after the start of treatment and then subsequently suppressed during long-term exposure to the agent. The level of MMP-9 in the plasma of these patients was highly variable and no active enzyme was detected. Studies are under way to determine if this variation is seen in subjects that are cancer free. We have generated preliminary data that suggest that PARP cleavage, Bcl-2 protein levels and Raf and MAPK phosphorylation state may be useful markers of Bryostatin action.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA346618

Entities

People

  • Michael D. Johnson

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biomedical Research
  • Blood
  • Blood Cells
  • Breast Cancer
  • Cancer
  • Capillary Electrophoresis
  • Cell Physiological Processes
  • Cells
  • Clinical Trials
  • Enzymes
  • Institutional Review Board
  • Kinases
  • Lymphocytes
  • Metastasis
  • Molecules
  • Neoplasms

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).