Molecular Diagnosis for Breast Malignancy
Abstract
This grant investigates the role of EMMPRIN, seprase and DPPW in breast cancer invasion and metastasis. The aims are to evaluate these conceivable invasion-related molecules as prognostic markers for node-negative breast cancer. We identified, cloned and expressed a full-length cDNA that encoded for a human tumor derived collagenase-stimulating factor, called EMMPRIN. Vectors containing EMMPRIN sense and antisense inserts have been constructed and expression studies showed that EMMPRIN is expressed at invadopodia of invasive breast carcinoma cells where it interacts with membrane proteases and integrins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADA346680
Entities
People
- Wen T. Chen
Organizations
- Georgetown University