Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other Than BRCAl

Abstract

The purpose of this project was to identify genes responsible for inherited predisposition to breast cancer in families. The gene PTEN was successfully cloned by this project, and simultaneously by others (for a different reason) and proved to be such a gene. This project indicated that inherited mutations in PTEN predispose to breast cancer in women with the rare Cowden's syndrome. However, symptoms of that syndrome may be very subtle, so breast cancer may be the first sign to appear. Inherited mutations in PTEN predispose to multiple other cancers that may appear with breast cancer in these patients. Also, this project demonstrated the value of patients with germline translocations and breast cancer for the identification of tumor suppressor genes.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADA346685

Entities

People

  • Mary-claire King

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Genetic Code
  • Genetic Phenomena
  • Genetics
  • Health Services
  • Hereditary Diseases
  • Identification
  • Medical Genetics
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Uterine Cancers

Fields of Study

  • Medicine

Readers

  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology