Cell Signaling by a Novel SH2 Domain Protein that is Overexpressed with Her2 in Breast Cancer

Abstract

The goal of this project is to determine the role of the Src Homology 2 (SH2) domain protein, Grb7, in tyrosine kinase signal transduction. Grb7 is overexpressed in approximately 20% of breast cancers in combination with the HER2 receptor tyrosine kinase. Our initial goals of this project were to determine the role of Grb7 overexpression on breast cancer cell behavior as well as to identify proteins that interact with Grb7. Our initial studies have not indicated a specific phenotype induced by Grb7 overexpression or specific proteins that can associate with Grb7. In order to determine a function for Grb7, we are currently generating a mouse deficient in Grb7.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1998
Accession Number
ADA346698

Entities

People

  • Benjamin L. Margolis

Organizations

  • NYU Langone Health

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biological Sciences
  • Biology
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Fibroblasts
  • Genetic Structures
  • Molecular Biology
  • Neoplasms
  • New York
  • Polymerase Chain Reaction
  • Stem Cells

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).