Vasopressin Gene-Related Products in the Management of Breast Cancer

Abstract

The goal of this project is to improve the detection and treatment of breast cancer by characterizing vasopressin gene expression by this disease and determining the nature and role of products generated through this expression. We have now demonstrated that the vasopressin gene is expressed by seemingly all carcinoma in situ, and this new information added to an absence of vasopressin gene-related products from fibrocystic disease should provide us with a new screening test for distinguishing carcinoma in situ from atypical intraductal hyperplasia. Our recent studies on cell trafficking in breast cancer of vasopressin gene-products have shown that almost all protein processing is outside of conventional secretory vesicles, and components of glycopeptide-related cell surface antigen (GRSA) comprise both the 20 KDa and 40 KDa vasopressin-related proteins we have been characterizing. Therefore both of these proteins are potential targets for immunotherapy.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA346786

Entities

People

  • William G. North

Organizations

  • Dartmouth College

Tags

DTIC Thesaurus Topics

  • Antigens
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cell Membrane
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Dna Sequence Analysis
  • Gene Expression
  • Genetic Code
  • Medical Personnel
  • Neoplasms
  • Pituitary And Hypothalamic Hormones And Analogues
  • Proteins
  • Skin Diseases

Fields of Study

  • Biology

Readers

  • Chemistry (specifically Chemical Fluorescence)
  • Molecular Biology and Genetics
  • Molecular and Cellular Biochemistry

Technology Areas

  • Biotechnology