Paclitaxel (Taxol) Resistance in Breast Cancer Cells.

Abstract

With reference to the three tasks of this project, as noted in the prior report, we have completed task 1 (Development of resistance to taxol alone). This current report focuses on task 2 (double selection of resistance to taxol and PSC 833) and task 3 (investigation of taxol resistant mutants). We have developed cellular models of breast cancer cells resistant to both taxol and the combination of taxol with PSC 833, a potent inhibitor of MDR1. These cells demonstrate alterations in apoptosis regulating proteins as well as tubulin isotypes. The relationship of these changes to the resistance phenotype of these cells is currently being explored.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA349565

Entities

People

  • Branimir I. Sikic

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Reactions
  • Chemotherapeutic Agents
  • Genes
  • Genetic Structures
  • Inhibitors
  • Materials
  • Neoplasms
  • Phenotypes
  • Polymerase Chain Reaction
  • Resistance

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).