Identification of Mammary Specific Transcription Factors.
Abstract
The Mouse Mammary Tumor Virus (MMTV) which causes mammary carcinomas in mice has been used a model system to study the influence of chromatin structure on gene regulation and the mechanism for mammary tissue specific gene expression. MMTV is expressed most highly in the mammary gland during pregnancy and lactation and infection of the pups occurs when viral particles are secreted in the milk. Therefore, it has been suggested that the MMTV LTR may be regulated in a similar manner to other milk protein genes. During pregnancy the alveolar epithelial cells form alveoli which secrete milk proteins directionally into a central lumen in response to prolactin, growth hormones and glucocorticoids. The transcription process by which the milk proteins are regulated has been characterized for several of the genes including Whey acidic protein (WAP) and Beta-casein.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1998
- Accession Number
- ADA349836
Entities
People
- Julia M. Michelotti
Organizations
- National Institutes of Health