Selection and Characterization of Drug Resistant Variants of Human Immunodeficiency Virus.

Abstract

A major concern in the pursuit of effective therapies for human immunodeficiency virus (HIV) infection is the potential for HIV to develop drug resistance. The therapeutic efficacy of all currently licensed antiretrovirals is limited by the emergence of drug resistant HIV strains. Several promising new inhibitors of HIV reverse transcriptase (RT) and combinations of protease inhibitors are entering clinical trial, but inadequate information is available about the potential for HIV resistance to these therapies. The isolation and molecular characterization of drug resistant HIV variants that emerge in cell culture with drug selection has helped predict both the likelihood of resistance and the types of resistant mutants that appear in treated patients. Thus, the overall goal of this one year project was to continue to evaluate RT inhibitors for the development of HIV resistance.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1997
Accession Number
ADA349979

Entities

People

  • John W. Mellors

Organizations

  • United States Department of Veterans Affairs

Tags

DTIC Thesaurus Topics

  • Acquired Immune Deficiency Syndrome
  • Anti-Infective Agents
  • Antiviral Agents
  • Chemical Synthesis
  • Chemistry
  • Dna Sequence Analysis
  • Enzyme Inhibitors
  • Health Services
  • Hiv Infections
  • Infection
  • Lymphocytes
  • Medical Personnel
  • Organic Chemistry
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

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  • Immunology
  • Oncology (Cancer Research).