The Identification of Genes Mediating Chemo-Sensitivity in Human Mammary Cells
Abstract
Our working hypothesis is that the loss of function of a number of diverse checkpoint molecules will lead to the proliferation of chemo-resistance tumor cells, and that the various molecules altered will be specific for any given class of chemotherapeutic agent. Besides the p53 pathway, relatively little is known regarding other checkpoint molecules whose loss of function results in chemo-resistance. This is probably due to the fact that loss of function of these molecules occurs through very subtle genetic alterations which are not easily detected by any current molecular techniques. Research performed under this award is focusing on identifying genes whose loss of function results in the proliferation of tumor cells that are resistant to the action of two different types of drugs (i.e.; adriamycin and taxol) that are used to treat women with breast cancer. This is being performed with a novel system that allows for the isolation of genes encoding selectable recessive phenotypes. Identifying molecular pathways that are altered in chemo-resistance malignant cells will be a critical step for the future design of novel therapeutic strategies that aim to restore chemo-sensitivity to chemo-resistant breast tumor cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1998
- Accession Number
- ADA350940
Entities
People
- Dale Haines