The Role of Phosphotyrosine Phosphatases in Breast Cancer.

Abstract

This report describes the development and synthesis and assaying of a new class of Yop5l inactivators. The conclusions from this work are: (1) alpha-bromoaryphosphonate is the basic inactivator molecule active against Yop51; (2) planar aromatic systems appear to bind well to the enzyme active site; (3) incorporating the basic inactivator functionality into a benzodiazepine template yielded the most potent inactivator.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1998
Accession Number
ADA352315

Entities

People

  • Juliatiek Rosetamadji

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Enzymes
  • Ethers
  • Laboratory Animals
  • Materials
  • Molecules
  • Neoplasms
  • Proteins
  • Recombinant Dna
  • Template Patterns
  • Tyrosine

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry