Ultrashort Laser Pulse Effects on Ocular Tissue: Histopathologic Analysis and Surgical Techniques.
Abstract
Toth et al. identified the acute pathologic retinal events which determined the extent of tissue damage from minimal laser energy and suprathreshold energy. She identified the acute pathology of primate maculas with minimal visible retinal lesions generated by 90 femtosecond and 5 picosecond pulses of 580 nm laser energy. Dr. Toth's study included light microscopic evaluation of macular damage and electron microscopic ultrastructural analysis of melanosome ruptures within the retinal pigment epithelium. The pathology was reported at AFOSR with a CDROM summary of lesion data provided to armstrong Laboratory for reference. Dr. Toth scored the area and extent of tissue damage and compiled a list for Dr. Rockwell and Dr. Clarence Cain at Armstrong Laboratory, Brooks, AFB for analysis and comparison to the ED50 MVL data. A paper summarizing this work has been published as the lead article in October, 1997 in Investigative Ophthalmology and Visual Science (I0VS). Dr. Toth's Laboratory group gathered significant tissue data on ultrashort pulses of other laser wavelengths. They collaborated with Armstrong Laboratory (Dr. Cain et al.) in analyzing near-infrared ultrashort laser pulse injury MVL data which was published at Society of Photo-Optical Instrumentation Engineers (SPIE), 1997 (Cain, Toth, et al.).
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 14, 1998
- Accession Number
- ADA352998
Entities
People
- Cynthia A. Toth
Organizations
- Duke University Hospital