Prevalence and Characterization of BRCA2 In Male Breast Cancer Cases
Abstract
Male breast cancer (MBC) is rare, with an incidence rate of 0.5 - 1/100,000 per year. The objective of this grant is to study a series of unselected population-based MBC cases and their relatives to characterize the role of BRCA2 in MBC and to estimate the attributable risk of MBC due to BRCA2 mutations. At the end of this second year of funding, we have collected DNA samples on 124 MBC cases and paraffin-embedded tissue on 21 of those. Of the 80 MBC cases with available family history data, 44 (55%) have a family history of breast cancer in first or second degree relatives. To detect germline mutations in BRCA2, single strand conformational analysis (SSCA) of the DNA samples is being performed for seventy-four amplicons spanning the entire coding region and intron/exon boundaries. Ninety percent of the gene has been screened for mutations in 10 samples, 60% for 48 samples, and 50% for 66 samples.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADA353184
Entities
People
- Susan L. Neuhausen
Organizations
- University of Utah