Novel Mechanisms of Mammary Oncogenesis by Human Adenovirus Type 9

Abstract

Human adenovirus type 9 is unique among oncogenic adenoviruses in generating estrogen-dependent mammary tumors in rats. The Ad9 E4 open reading frame 1 9ORFl oncogene is the major oncogenic determinant of this virus. 9ORFl codes for a polypeptide related to the enzyme dUTP pyrophosphatase, although it lacks this enzymatic activity. The 9ORF1 protein also possesses a functional PDZ domain-binding motif at its C-terminus and disruption of this motif abolishes its transforming activity. PDZ domains are protein-protein interaction modules found in a novel class of cell signaling proteins that localize to specialized membrane sites in cells. Significantly, we have now identified two cellular PDZ-domain proteins (DLG and 9BP- 1) that bind to the 9ORF1 oncoprotein. We hypothesize that these cellular factors are critical components of signaling pathways involved in the control of cellular proliferation and in oncogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA353770

Entities

People

  • Ronald T. Javier

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Amino Acids
  • Animals
  • Biomedical And Dental Materials
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Immune Serums
  • Intercellular Junctions
  • Molecules
  • Neoplasms
  • Polymeric Films
  • Protein-Protein Interactions
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics