Determinants of Human Breast Epithelial Cell Estrogen Receptor Expression and Differentiation: Organization and Environment

Abstract

Breast cancer presumably originates in an estrogen receptor-positive (ER +), estrogen (E2)-responsive epithelial cell within organized human breast tissue. It is a paradox that there is an exceedingly low level of, and few cells expressing, ER in normal breast tissue, and human breast epithelial cell lines (HBE-CL) lack ER and do not respond to E2. Our hypothesis is that human breast parenchymal epithelial cell-cell interactions and epithelial stromal interactions are critical in vitro determinants of HBE cell ER expression and biochemical differentiation.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1998
Accession Number
ADA353772

Entities

People

  • Robert Pauley

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Environment
  • Epithelial Cells
  • Estrogens
  • Fibroblasts
  • Growth Factors
  • Mammary Glands
  • Materials
  • Membranes
  • Neoplasms
  • Stromal Cells
  • Three Dimensional
  • Tissues

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics
  • Systems Analysis and Design