Cloning of Novel Oncogenes Involved in Human Breast Cancer
Abstract
The genetic determinants which lie behind the development of breast cancer remain largely uncharacterized. In order to identify genes which may play a role in breast cancer we have begun a process of manufacturing cDNA expression libraries derived from human breast tumor cell lines in retroviral vectors. These libraries will be screened for their ability to induce a transformed phenotype in non-transformed or sub-transformed breast epithelial cells. The genes responsible for the transformation will be isolated with the goal of identifying important new markers for tumorigenesis which may serve as the targets for intervention or diagnosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1998
- Accession Number
- ADA353775
Entities
People
- Geoffrey Clark
Organizations
- University of North Carolina at Chapel Hill