Integrin Regulation of Apoptosis in Breast Cancer.

Abstract

This project aimed to study a novel gene, ADAMx, which was found in human breast tumor MCF-7. Partial sequence of ADAMx reveals that it constitutes domains characteristic of the ADAM proteins. Furthermore, ADAMx appears to be tile human analog of fertilin-a. So far, experiments have focused on DNA cloning and antibody production. Unfortunately, upon further study, ADAMx was found to be a pseudogene as marked by stop codons at the 5'-end of the transcript and an insertion and deletion sequences in the region. This result was confirmed and published by another group of scientists. This is a rather unexpected result for this proposal and for my research career. However, for the scientific community as a whole, it would still be interesting to conduct research in order to interpret this result, especially from evolution point of view.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA353840

Entities

People

  • Dana Hu

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Apoptosis
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Genetic Code
  • Genetic Structures
  • Genetics
  • Molecules
  • Neoplasms
  • Peptides
  • Proteins
  • Rodents
  • Tumor Cell Line

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).
  • Research Science/Academic Research