A New Class of Serine and Cysteine Protease Inhibitor with Chemotherapeutic Potential.

Abstract

Metastasis and angiogenesis in cancer are dependent on a variety of biologically active compounds including serine proteases. Inhibition of proteases such as plasmin is a potential route for suppression of both metastasis and angiogenesis. Synthesis of tetrahydrothiopyran-4-one based inhibitors containing either a diamine or a lysine analog diamino acid side chain was undertaker. The diamine and diamino acid inhibitors have inhibition constants of 500 micrometer and 40 micrometer respectively. Synthesis of a piperidone derivative inhibitor was completed.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA353868

Entities

People

  • Tanya C. Sanders

Organizations

  • Brown University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Angiogenesis
  • Biomedical Research
  • Blood Coagulation Factors
  • Blood Vessels
  • Chemical Synthesis
  • Chemistry
  • Cysteine
  • Enzyme Inhibitors
  • Fibrin Modulating Agents
  • Inhibition
  • Inhibitors
  • Materials
  • Metastasis
  • Neoplasms
  • Neutral Amino Acids
  • Sulfur Compounds

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).
  • Polymer Science and Technology