Genes Controlling Susceptibility to Mammary Cancer.
Abstract
This report documents results from DAMDl7-97-l-7123, which is designed to identify nutritionally modulated genetic loci in the mouse that alter susceptibility to breast cancer. Calorie restriction (CR) is a potent nutritional intervention, demonstrated to reduce carcinogen induced mammary tumors in rodents. We demonstrate the modifications necessary to adapt a protocol for inducing mammary tumors with carcinogen in rats for use in mice. The study underway is currently documenting the relative mammary tumor prevalence in 8 inbred strains of mice after being dosed with carcinogen. The mice in each genotype have been divided into two dietary groups, control and CR. CR has been successfully implemented in all 8 strains after the mice were treated with carcinogen, demonstrating the feasibility of this nutritional intervention after carcinogen treatment. Among genotypes, two parameters demonstrate genotypic variability; 1) average body weight in ad libitum fed controls as a function of age and 2) caloric intake necessary to result in a 30 to 40% reduction in body weight in CR cohorts. Mammary adenocarcinomas have been observed in S of the 8 inbred strains being studied. Taken together, these observations suggest that this work will identify differences in response to CR among mouse genotypes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADA354065
Entities
People
- Ruth D. Lipman
Organizations
- Tufts University