Hormone Resistance and Progesterone Receptors in Breast Cancer

Abstract

The overall goal of the proposed research has been to understand the mechanisms by which breast cancers become resistant to hormone treatments. Specifically, the hormones involved are the steroidal agonists, estradiol and progesterone, the antagonists tamoxifen and RU-486, and the receptors to which these hormones bind, namely estrogen (ER) and progesterone receptors (PR). To this end, we initially used as models, the PR of human breast cancer cells and the antiprogestin RU-486. We anticipated that the mechanisms we uncovered for progestins would be relevant to estrogens as well. This has turned out to be the case. We have discovered two proteins, which interact with antagonist-occupied receptors, and alter the direction of receptor-dependent transcription.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1998
Accession Number
ADA354075

Entities

People

  • Kathryn B. Horwitz

Organizations

  • University of Colorado Health

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Anti-Bacterial Agents
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Genetic Code
  • Genetics
  • Liquid Chromatography
  • Molecular Biology
  • Neoplasms
  • Proteins
  • Rodents
  • Tumor Cell Line

Readers

  • Breast cancer cell signaling and growth regulation.