Role of Estrogen Receptor Target Genes in Breast Cancer

Abstract

The aim of this project is to understand the mechanism of transition of breast cancer from hormone-dependent state to hormone-independent state. In order to pursue this question we have designed a regulatable regulator that can recognize all estrogen receptor target genes and put them under the regulation of exogenous compound RU486. In the presence of RU486, this regulator can bind to all estrogen targets and shut down their expression. We want to use this regulator to study the role of estrogen receptor target genes on breast cancer cell growth in hormone-dependent and hormone-independent states. In the last year, using a cellular culture system, we have successfully constructed this regulator and demonstrated that it can shut down a estrogen receptor reporter gene.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA354076

Entities

People

  • Ming-jer Tsai

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Compounds
  • Diseases And Disorders
  • Epithelial Cells
  • Hormones
  • Laboratory Animals
  • Materials
  • Medical Personnel
  • Neoplasms
  • Recombinant Dna
  • Transitions
  • Translations
  • Tumor Cell Line

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