The Role of BRCA1 in Normal Mammary Epithelial Development and Tumorigenesis.

Abstract

Germline mutations in BRCA 1 account for about 45% of all hereditary cases of breast cancer. However, the role of BRCA 1 in mammary tumorigenesis is not established. My proposal outlines two approaches to extend our knowledge of BRCAl function in normal development and malignant transformation. First, I used the cre-lox system to generate a mouse model in which loss of ERCAl is limited to mammary epithelium. Four different mouse lines expressing the Cre recombinase in mammary epithelium were generated, and we are currently working towards generating a lox-Brcal-lox mouse.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1998
Accession Number
ADA354094

Entities

People

  • Victoria Lee

Organizations

  • University of North Carolina at Chapel Hill

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Deficiencies
  • Embryos
  • Epithelial Cells
  • Epithelium
  • Genes
  • Genetic Structures
  • Genetics
  • Mammary Glands
  • Medical Personnel
  • Tissues

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.