Hemoglobin-Based Oxygen-Carrying Resuscitation Fluids.
Abstract
Currently, transfusion of donor blood is the conventional treatment for profound hemorrhagic shock (?ATLS). However, very significant problems are inherent in human blood transfusions. First, there is an increasing shortage of donors which becomes more severe due to the rising incidence of AIDS carriers in blood- donating populations (5). Second, red blood cells carry multiple antigenic determinants so that donor blood must be carefully typed and cross-matched before administration, a time-consuming and mostly process. Third, blood has a limited "shelf-life" due to short storage viability, which at the present does not exceed one month. Fourth, blood storage and distribution is logistically- demanding because it must be stored and delivered at 40C. Finally, blood can carry virally-transmitted diseases such as AIDS and hepatitis. Therefore, there is a profound clinical, economical and logistical demand for a non-antigenic, disease-free, easily transportable and long-term storable blood substitute.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1994
- Accession Number
- ADA355452
Entities
People
- Feuerstein Giora
- Neville F. Lewis
- Rabinovici Reuven
- Rudolph S. Alan
Organizations
- Thomas Jefferson University