Mutations in ATM, Radiation Exposure and Breast Cancer Risk Among Black and White Women.
Abstract
In some families, predisposition to breast cancer is inherited as a genetic trait. Thus far, a few highly penetrant genes responsible for inherited breast cancer have been identified. An important and unresolved question of breast cancer etiology is whether there are other genes which have a more moderate effect on breast cancer risk, possibly involving more women than do other inherited mutations. It has been suggested that mutations in the Ataxia- Telangiectasia gene (ATh) and cellular damage such as radiation exposure could be involved with breast cancer in this manner. In order to address this question, we are screening a population-based series of African-American and Caucasian breast cancer patients and controls as well as a series of patients with particular phenotypes for mutations in the ATM gene. This study will detect potential mutations in the ATh gene which confer breast cancer risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1998
- Accession Number
- ADA356148
Entities
People
- Elizabeth L. Schubert
Organizations
- University of Washington