Role ot Bone Sialoproteins in Osseous Metastasis of Breast Cancer.

Abstract

Bone Sialoprotein (BSP), a secreted glycoprotein normally found in bone matrix, is implicated in the formation of mammary gland microcalcifications and localized to approximately 80% of primary human breast cancers. This project utilized cDNA transfection methodology to examine the role of BSP in human breast cancer invasiveness and bone metastasis. In addition, the project characterized a new human breast cancer cell lines isolated from a metastatic lesion in the femur.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA356166

Entities

People

  • Victoria Sung

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Bone And Bones
  • Bone Diseases
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Cultured Cells
  • Health Services
  • Neoplasms
  • Tumor Cell Line

Readers

  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.