Breast Cancer Following Pediatric Hodgkins Disease: Risk Factors and Intervention.
Abstract
Analysis of a cohort of 1380 survivors of childhood Hodgkin's disease (HD) has shown a 75-fold increased risk of breast cancer, with the cumulative probability of developing breast cancer approaching 35% by 40 years of age among the female survivors of HD. We hypothesized that patients with HD who develop breast cancer have a genetic susceptibility to do so. The purpose of this proposal was to identify a subpopulation among the survivors of HD, at an increased risk for developing breast cancer, and to institute intervention in the form of active screening and possibly chemoprevention. Construction of pedigrees of patients with secondary breast cancer has failed to reveal excess of cancer among family members. We also planned to identify somatic and/or germline mutations in candidate genes known to be associated with breast cancer, including p53, BRCA1 and ATM. Four of the six breast cancer samples examined so far, contained mutations in exons 5-9 of the p53 gene. We plan to institute a surveillance protocol in HD patients at high risk of developing secondary breast cancer, to look at the efficacy of mammography as a screening tool in early detection of breast cancer and in reducing mortality.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADA357257
Entities
People
- Leslie Robison
Organizations
- University of Minnesota