Oligosaccharide Markers for Prognosis of Low-Risk Breast Cancer.
Abstract
Earlier results from this project suggested that the prognosis for patients with node-negative ductal breast carcinomas was poor, when tumor cells expressed the cell-surface Lea-LeX cell-surface oligosaceharide. However, the statistical significance of this finding was lost, when results obtained during the past year analyzing tumor specimen from the last 95 patients of this study were included in the statistical analysis. Certain technical problems were encountered during the immunohistochemical analysis of this last set of patients and we are currently attempting to correct these and to re-analyze duplicate specimens. Analysis of the cell surface oligosaccharides Lea, Tn, T antigen, sialyl- Lea, and LeX showed no significant correlations with prognosis. Other related studies led to the identification of two new cDNA clones whose cognate genes are overexpressed in Lea-Lex? positive cancer cells. Partial DNA sequencing has indicated that these clones are partially homologous to known human fucosyltransferases. The cognate genes for these clones are candidates for those that are aberrantly expressed in cancer cells that are Lea-LeX positive.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA357341
Entities
People
- David E. Pettijohn
Organizations
- University of Colorado Boulder