Mammary Gland Ontegeny and Neoplasia in Oxytocin Deficient Mice.

Abstract

The studies utilize oxytocin "knock-out" and wild type mice (homozygous for the oxytocin gene) to test the hypothesis that diminished oxytocin and the absence of its effect upon the mammary gland, may in part predispose the breast to neoplastic change and its corollary that exposure to oxytocin may be protective. The technical objectives of this proposal as follows. 1) Determine the prevalence of mammary neoplasia in the progeny of MMTV-infected mice that are bred with OT KO versus WT mice, 2) Determine if there are differences in the susceptibility of MMTV- infected KO versus MMTV-infected WT mice to develop mammary neoplasia when exposed in vivo to ovarian steroid hormones. If oxytocin is shown to be an important factor in breast cancer, exogenous oxytocin may be a potential safe, non-toxic measure in its prevention.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA357697

Entities

People

  • Janet A. Amico

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Anti-Bacterial Agents
  • Birth
  • Brain
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Gene Expression
  • Genetics
  • Glands
  • Mammary Glands
  • Materials
  • Molecular Dynamics
  • Neoplasms
  • Neurosecretory Systems
  • Pituitary And Hypothalamic Hormones And Analogues

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.