Functional Analysis of Nova Proteins: Gene Regulation and Breast Tumor Immunity.

Abstract

The investigation and molecular characterization of the paraneoplastic neurological disorders (PNDs) has provided the means to explore the elements of effective tumor immunity. The PNDs are autoimmune diseases which appear to develop when tumor express proteins that are normally expressed only in neurons. One of the best studied PNDs, paraneoplastic opsoclonus-myoclonus-ataxia (POMA), is a motor disorder, and is most frequently associated with occult breast tumors. Antisera from POMA patients identifies a 55 kDa RNA-binding protein in both tumor and normal brain specimens, and has been used to expression clone the gene responsible for this antigen, Nova.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA358057

Entities

People

  • Kirk B. Jensen

Organizations

  • The Rockefeller University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Autoimmune Diseases
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Chemistry
  • Diseases And Disorders
  • Functional Analysis
  • Immune Serums
  • Immunity
  • Materials
  • Molecules
  • Motor Disorders
  • Movement Disorders
  • Neoplasms
  • Proteins

Fields of Study

  • Biology
  • Medicine

Readers

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